Date of Award
5-2024
Access Control
Campus-Only Access
Degree Name
Forensic Science, M.S.
Department
Chemistry Department
Advisor
Dr. Sujit Suwal
First Reader
Dr. Sujit Suwal
Second Reader
Dr. Jamie Kim
Third Reader
Dr. Jinseok Heo
Abstract
Curaxins are small molecules that have demonstrated anti-cancer activity through the activation of p53 and inhibition of nuclear factor-kB. Curaxins interfere with DNA-histone interactions, impeding DNA repair and inducing chromatin destabilization. This leads to apoptosis through alterations in spatial genome organization and oncogene expression. The results are due to DNA binding activity. A team of researchers, including a Roswell Park Cancer Institute group, discovered these molecules. This project aims to synthesize a diverse library of novel analogs of curaxin through a modified literature protocol to enhance the chemotherapeutic potency while minimizing non-specific cytotoxicity. N-alkylation of diacetyl carbazole followed by saponification results in acid subjected to amide coupling to create functionally diverse chemical scaffolds. The pure intermediates are authenticated using spectroscopic methods. The efficacy of the compounds is tested against renal cell carcinoma cell lines by luciferase reporter assays and compared across analog variants.
Recommended Citation
Brown, Elizabeth E., "Synthesis and Structure of Curaxin Analogs" (2024). Forensic Science Master's Projects. 15.
https://digitalcommons.buffalostate.edu/forensic_science_projects/15
Note: To access this document you must have a Digital Commons account using a valid Buffalo State email address or be accessing the internet through the Buffalo State campus network.
Included in
Analytical Chemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Organic Chemistry Commons
