Comparative Analysis of Genuine Acetaminophen Tablets by Raman Scattering and Chemometrics
The use of Raman spectroscopy with Chemometric analysis has been well documented as an effective method for the identification of counterfeit pharmaceutical products. Due to an ongoing concern about the lack of transparency surrounding the manufacturing of generic pharmaceuticals in the US, this project aimed to examine the utility of the method for the differentiation of generic pharmaceuticals. A testing pool of ten acetaminophen samples was obtained and representative tablets were characterized by Raman spectroscopy. The results were then projected using principal component analysis which revealed discrete groupings of brands. The project provides proof of concept for the differentiation of genuine articles by Raman spectroscopy and chemometrics and the potential for the method to be used for classification and prediction of products.
Dr. Jinseok Heo
Good, Elisabeth M., "Comparative Analysis of Genuine Acetaminophen Tablets by Raman Scattering and Chemometrics" (2021). School of Natural and Social Sciences. 2.